Rituximab Therapy for Refractory Autoimmune Thrombocytopenia in Systemic Lupus Erythematosus
نویسندگان
چکیده
منابع مشابه
Rituximab Therapy for Refractory Autoimmune Thrombocytopenia in Patients with Systemic Lupus Erythematosus
Systemic lupus erythematosus (SlE) and autoimmune polyendocrinopathy are characterized by autoantibodies against a variety of target organs. Traditional treatment strategies for immune cytopenias include global immunosuppression that targets both the humoral and cell-mediated arms of the immune system. B-cells play an important role in the pathogenesis of many autoimmune diseases. Targeted depl...
متن کامل[Treatment with rituximab for thrombocytopenia due to systemic lupus erythematosus].
UNLABELLED Some patients with thrombocytopenia due SLE fail to respond to conventional therapies. Rituximab has been reported to be an alternative for patient treatment. OBJECTIVE To evaluate the response of thrombocytopenia due to Systemic Lupus Erythematosus to the use of Rituximab and patient relapse time at our hospital. PATIENTS AND METHODS We analyzed patients with SLE than received a...
متن کاملSplenectomy for refractory thrombocytopenia in juvenile systemic lupus erythematosus
Background The prevalence of autoimmune thrombocytopenia in juvenile systemic lupus erythematosus (JSLE) ranges from 7–52% (mean 14,5%) but profound rates (<50,000/mL) are uncommon. Although the exact mechanism is unknown, the spleen has been implicated either as the source of antiplatelet antibodies or the site of sensitized platelets destruction. Splenectomy is rarely indicated due to the inc...
متن کاملEfficacy and Safety of Rituximab in Systemic Lupus Erythematosus and Sjögren Syndrome Patients With Refractory Thrombocytopenia
Objective: Recent studies suggested a potential of rituximab (RTX) in treating autoimmune thrombocytopenia (AITP) secondary to autoimmune diseases. In this study, we retrospectively evaluated the efficacy and safety of RTX therapy in patients with refractory AITP secondary to systemic lupus erythematosus (SLE) and Sjögren syndrome (SS). Methods: Twenty-one SLE and/or SS patients with treatment-...
متن کاملRefractory Angioedema in a Patient with Systemic Lupus Erythematosus
Angioedema secondary to C1 inhibitor deficiency has been rarely reported to be associated with systemic lupus erythematosus. A genetic defect of C1 inhibitor produces hereditary angioedema, which is usually presented with cutaneous painless edema, but edema of the genital area, gastrointestinal and laryngeal tracts have also been reported.In lupus patients, angioedema may be the result of an ac...
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ژورنال
عنوان ژورنال: Turkish Journal of Hematology
سال: 2012
ISSN: 1300-7777,1308-5263
DOI: 10.5505/tjh.2012.26539